Crosslinks | Life Sciences Redefined » Portfolio

Nutrigenomics Project

admin — Thu, 08 Mar 2012 09:06:16 +0000

The mission of the Division of Human Nutrition at Wageningen University is to ‘improve human health through better nutrition’.

To support the Division of Human Nutrition in their research, Crosslinks has recently designed and implemented a database schema to store metadata from their nutrition-based experiments. The database was designed in a flexible way to cope with changes in the metadata attributes without altering the table structure of the database. The metadata is captured using the metadata-capturing tool GSCF and automatically uploaded to the database. The flexible design of the database combined with the use of GSCF enables biologist to capture, store and change their metadata attributes easily and in a user friendly way.

Pediatric support services

Kim — Thu, 31 Mar 2011 09:15:21 +0000

Crosslinks was selected by Sophia Children’s Hospital in Rotterdam to continue work on two existing pediatric projects.

Crosslinks has developed a new website that provides links to two existing applications for the Hospital. For the first of these applications, known as “PAOS” (Post Academic Education at Sophia), Crosslinks has created a new website which provides information and registration capabilities to surgeons and doctors from within Sophia to attend after-hours courses where they can receive instruction on a range of new and different pediatric medical techniques.

The second application is being hosted and maintained by Crosslinks and contains an international database: EuroKids IBD. This application collects and stores data relating to pediatric patients suffering from Inflammatory Bowel Disease.

iNeo Stroke

admin — Thu, 10 Feb 2011 12:00:37 +0000

iNeo Stroke has been developed as an interactive brain atlas for use in neonatal neurological care. The application allows clinicians around the world to access relevant reference information regarding brain lesions and stroke symptoms/occurrences via a personal iPhone.

See our products page for more information.

Biochip: microarray-based diagnoses of Acute Myeloid Leukaemia

admin — Thu, 10 Feb 2011 11:50:21 +0000

Crosslinks has produced a robust diagnostic analysis platform in collaboration with Skyline Diagnostics to deliver a state-of-the-art microarray-based prognoses for Acute Myeloid Leukaemia (AML) patients. The system enables speedy and accurate identification of Leukaemia sub-types so that the most effective subtype-specific treatments can be employed as quickly as possible.

The system is based on an innovative centralized architecture that offers key advantages over “on-device” processing:
Simpler development and validation and updating improves quality
Single secured environment ensures Signature IP protection

The AMLProfiler is entering final clinical trials in the second half of 2012 and represents a world-first in delivery of a complex prognostic device to FDA standards that takes advantage of modern networking to centralize processing in this way.
The platform is designed to be compliant with the stringent demands of the EU and United States Federal Drug Agency (FDA) and it is expected that it will be available – either as software as a service (SAAS) or as an “in house” solution – for other companies looking to develop similar products using novel diagnostic technologies such as microarrays or NGS.

The Biochip project is funded through the Netherlands CTMM (Centre for Translational Molecular Medicine) initiative.
CTMM Project page
Skyline

Automatic rapid identification of bacteria

admin — Thu, 10 Feb 2011 11:40:15 +0000

In this project Crosslinks is supporting one of our partners in the development of a diagnostic module that makes the rapid diagnosis of bacteria possible. The final integration of the diagnostic module into our diagnostic analysis platform (vDAP) will enable hospitals to remotely diagnose their patients quickly and will consequently change the way patients are treated. The new technique developed by our partner is based on targeting particular parts of bacterial genomes, which are specific for different bacterial species.

Because of heavily overlapping symptoms, bacterial diagnosis and treatment of infectious diseases is difficult based on clinical symptoms only. Therefore, patients are often treated empirically. More efficient treatment and management of infectious diseases, however, requires rapid point-of-care in vitro diagnostic methods.

Analysis of patients with ischemic cerebrovascular disease

admin — Thu, 10 Feb 2011 11:30:55 +0000

The quantification of the affected areas of brain with ischemic cerebrovascular disease (from MRI images) using automated analysis of brain imaging in order to have additional and more objective data that can be associated with genotypes. Analysis of single nucleotide polymorphism (Illumina 610k) of patients with ischemic cerebrovascular disease. Automated image processing of brain MRI (dicom files) data and comparison of quantitative analysis of pathological regions in multi-slice vs volume brain MRI of patients with ischemic cerebrovascular disease. Data integration for genotype and phenotype results. Statistical analysis of genotype to phenotype association.

KinCor (Congenital Heart Disease)

admin — Thu, 10 Feb 2011 11:20:23 +0000

The purpose of the KinCor project is to develop a registration system for the support of clinical research in pediatric cardiology. The focus of this rapidly developing speciality is on congenital, aquired, and hereditary abnormalities of the heart and vascular system in children. All academic departments for pediatric cardiology in the Netherlands will participate in this registration that will provide reseachers with a valuable resource for future clinical studies.

In this project Crosslinks is responsible for the development of the system (functional design and implementation) and works in close collaboration with the participating clinical partners. In addition to this Crosslinks has an advisory role on organizational, financial, and legal aspects of the project.

Project website: http://www.kincor.nl

Project is funded by the Dutch Heart Foundationand the NFU, the Dutch Federation of University Medical Centers.

Kinderformularium (nkfk)

admin — Thu, 10 Feb 2011 11:10:08 +0000

Crosslinks has implemented a web application consisting of a database back-end and a web interface which is allowing Dutch pediatricians and pharmacists to access recommendations regarding optimal pediatric dosage for many over-the-counter and prescription medications. This “children’s formula” application is suitable for further development for use on mobile phones.

ESPE e-learning

admin — Thu, 10 Feb 2011 11:06:42 +0000

The ESPE e-learning web portal gives you an entrance to an interactive learning environment for up-to-date paediatric endocrinology knowledge. This web portal is made for medical students, residents, fellows, specialists, consultants and teachers around the world to collaborate in order to gain, share, contribute and develop knowledge in an accessible and flexible way. So far 3 major chapters have been constructed: Growth, Puberty and DSD. These chapters contain core modules aimed primarily at medical students but also advanced modules specifically aimed at post-doc students and other senior staff. Assignments are structured in such a way as to prompt critical thinking to enhance gains in knowledge and skills. In addition, formative assessment is given by providing feedback to steer the learning process.

Growth Analyser

admin — Thu, 10 Feb 2011 11:05:04 +0000

Growth Analyser is intended to support paediatricians and clinical researchers with the registration and analysis of growth and development data of their patients, using the best reference standards and analysis tools available, presented in an easy to use format. The tools includes 170 different country, regional, ethnic and diagnosis based growth curves.

http://www.growthanalyser.org/

Nephrotic Syndrome

admin — Thu, 10 Feb 2011 11:04:37 +0000

A patient registration system was built for the nephrotic children workgroup. This system is able to plot a patient disease profile and gives a disease classification. This schematic overview assists a diagnostician with the treatment for future patients.

NKFK website

admin — Thu, 10 Feb 2011 11:00:36 +0000

Our portfolio consist of many different types of projects including web design and development. An example of web design and development is the NKFK website.

The Dutch Expertise Centre for Paediatric Pharmacotherapy (NKFK) is a governmentally funded multidisciplinary expertise network that aims to improve the quality and safety of pharmacotherapy for children.

PreconceptieWijzer

admin — Wed, 09 Feb 2011 08:55:07 +0000

Preconception care includes all measures that can be taken before fertilization. Optimizing the health of the mother and her future child. By early identification and possible elimination of risk factors, adverse outcome of pregnancy, and diseases or abnormalities in mother and child can be prevented. Online tool for caregivers involved in preconception care, including obstetricians, gynecologists and general practitioners. PreconceptieWijzer makes it possible to consistently provide guidelines on preconception care.

PreconceptieWijzer was developed for the Erasmus MC and Star Diagnostic Medical Center in Rotterdam

Match study

admin — Tue, 08 Feb 2011 15:23:05 +0000

The identification by omics technologies of prognostic markers to predict colorectal cancer behavior and response to treatment especially as far as liver metastasis is concerned.
Objectives are to collect clinical data from patients with colorectal cancer. Organize regional follow-up regimen for diagnosing local recurrence and distant metastases. Store tissue, blood and urine in regional databank for omics profiling. Linking clinical and molecular data to develop tailor-made therapy for individual patients. Organize a research network in the Erasmus MC region that facilitates the implementation of more research and clinical protocols.

Analyzing Pepper Varieties using Single Feature Polymorphism

admin — Tue, 08 Feb 2011 13:12:54 +0000

DNA polymorphism is the basis for the development of molecular markers, an indispensable tool in genetic mapping studies and validating varieties of inbred plant species. Genetic differences between two sequences, originating from two different plant varieties, serve as a molecular marker popularly known as single feature polymorphism (SFP).

In this project the gene expression data of a pepper was obtained by hybridizing RNA to an oligonucleotide array, resulting in differential hybridization intensities. Crosslinks analyzed these intensities using statistical methods that looked at differences in varieties at the probe-level.

EU FP7 HiPerDART

admin — Tue, 08 Feb 2011 13:03:24 +0000

HiPerDART is an EU funded project project aiming to develop a higher standard (clinical) microarray technology platform, by using an innovative probe printing technology called Supramolecular NanoStamping (SuNS). Crosslinks’ role within the project is to perform quality control measurements to ensure they are comparable or superior to other established competing platforms. We also aim to verify the sensitivity and specificity of the signals in samples obtained in a clinical setting, and perform statistical analysis for the validation of the diagnostic profiles that have been generated. Once complete, the system will be made available for medical use by leveraging the (Biochip) analytical diagnostic platform technology.

Project call: FP7-HEALTH-2007-1.1-4
Project #:
Website:

EU FP7 MoodInflame

admin — Tue, 08 Feb 2011 11:13:54 +0000

Moodinflame is an EU funded project which was established to investigate the effect of inflammation on mood disorders in their various forms. Within the project, Crosslinks is responsible for regulating the security and reliability of all electronic clinical data. The software platform we are developing for this task includes a database and data management tools and there will be an upload and statistical validation portal added during the coming year. The large number of consortium members (18 partners across 10 countries) gives us a wonderful opportunity to perform gross statistical analysis over a range of institutes working on similar disorders. It also gives us all the ability to make connections between different disorders.

Project call: FP7- HEALTH-2007-2.2.1-8
Project #:
Website: http://www.moodinflame.eu
Article: How anti-depressants work

EU FP6 RATstream

admin — Mon, 07 Feb 2011 13:04:12 +0000

The different approaches of the RATstream consortium partners (behavioral testing, PET imaging data, and microarray data) generate large amounts of different types of data in their efforts to pinpoint the phenotypical characteristics of neurodegenerative diseases. Therefore, a central repository where the consortium partners can store and retrieve their data is necessary. Crosslinks provides this data-management solution via the RATstream server, which is controlled via a central database and allows us to upload, store and analyze all project data.

Project call: FP6-2005-LIFESCIHEALTH-7
Project #: LSHM-037846
Website: http://www.ratstream.eu/

Predictive profiling Tox study

admin — Mon, 01 Mar 2010 08:30:54 +0000

Various Affymetrix microarray-based data analyses to support our customer in their goal to generate a quality-controlled database of reference compound transcriptomic signatures to
fingerprint and categorize new compound toxicity.

Determination of TGF-beta induced genes and Smad4-dependent genes in NMuMG and MDA cells.

admin — Mon, 01 Mar 2010 08:25:24 +0000

Analysis of Affymetrix microarrays including experimental quality control per microarray and statistical analysis using groupwise comparisons.
Reporting overview of TGF-b signalling pathways in mice (NmuMG) and human (MDA MB 23). Basic off-target analysis.